ADORA1, adenosine A1 receptor, 134

N. diseases: 121; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0233612
Disease: Waxy flexibility
Waxy flexibility 		0.300 Therapeutic phenotype CTD_human Effect of adenosine receptor agonists and antagonists on morphine-induced catalepsy in mice. 9407998 1997
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0042510
Disease: Ventricular Fibrillation
Ventricular Fibrillation 		0.200 Biomarker disease RGD [Adenosine induces ventricular arrythmias in hearts with chronic chagas cardiomyopathy]. 20334814 2010
CUI: C0242698
Disease: Ventricular Dysfunction, Left
Ventricular Dysfunction, Left 		0.200 Biomarker phenotype RGD Adenosine A1 receptor expression during the transition from compensated pressure overload hypertrophy to heart failure. 17211253 2007
CUI: C0242973
Disease: Ventricular Dysfunction
Ventricular Dysfunction 		0.300 Biomarker phenotype CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma. 28950257 2017
CUI: C0040822
Disease: Tremor
Tremor 		0.010 GeneticVariation phenotype BEFREE We tested mice with essential-like tremor using current drug therapies that alleviate symptoms in essential tremor patients (primidone, propranolol, and gabapentin) and several candidates hypothesized to reduce tremor, including ethanol; the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801; the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA); the GABA(A) receptor modulators diazepam, allopregnanolone, and Ro15-4513; and the L-type Ca2+ channel antagonist nitrendipine. 15765150 2005
CUI: C0751020
Disease: Transient Ischemic Attack, Vertebrobasilar Circulation
Transient Ischemic Attack, Vertebrobasilar Circulation 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C1527335
Disease: Transient Ischemic Attack, Anterior Circulation
Transient Ischemic Attack, Anterior Circulation 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0917805
Disease: Transient Cerebral Ischemia
Transient Cerebral Ischemia 		0.300 Therapeutic disease CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0751848
Disease: Thrombotic Infarction, Middle Cerebral Artery
Thrombotic Infarction, Middle Cerebral Artery 		0.300 Therapeutic phenotype CTD_human Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. 23437309 2013
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 30224653 2018
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0472383
Disease: Subarachnoid Hemorrhage, Spontaneous
Subarachnoid Hemorrhage, Spontaneous 		0.300 Biomarker phenotype CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0795688
Disease: Subarachnoid Hemorrhage, Intracranial
Subarachnoid Hemorrhage, Intracranial 		0.300 Biomarker phenotype CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0751530
Disease: Subarachnoid Hemorrhage, Aneurysmal
Subarachnoid Hemorrhage, Aneurysmal 		0.300 Biomarker phenotype CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.300 Biomarker disease CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.020 Biomarker disease BEFREE Adenosine Induces EBV Lytic Reactivation through ADORA1 in EBV-Associated Gastric Carcinoma. 30875759 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.020 Biomarker disease BEFREE Taken together, our results suggest that the anti-cancer effect of Omega-3 PUFAs on gastric cancer is at least partly dependent on activating the ADORA1-mediated apoptosis pathway. 24896321 2014
CUI: C4551689
Disease: Sleep-Disordered Breathing
Sleep-Disordered Breathing 		0.010 Biomarker disease BEFREE During the second experiment, the effect of oral administration of adenosine A1 receptor antagonist (DPCPX, 3 times a day for 4 days) on SCI induced SDB was assessed. 31600096 2019
CUI: C0851578
Disease: Sleep Disorders
Sleep Disorders 		0.010 Biomarker group BEFREE Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. 30365112 2019
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.210 Biomarker disease BEFREE However, little is known about whether ADORA1 takes part in the course of neuronal cell injury after intermittent hypoxia exposure which was the main pathological characteristic of OSAHS. 29380238 2018
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.210 Biomarker disease RGD Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors. 18787037 2008